pySMT is a library for SMT formulae manipulation and solving, which makes working with Satisfiability Modulo Theory simple. Among others, the user can: - Define formulae in a solver independent way in a simple and inutitive way, - Write ad-hoc simplifiers and operators, - Dump your problems in the SMT-Lib format, - Solve them using one of the native solvers, or by wrapping any SMT-Lib complaint solver. pySMT provides methods to define a formula in Linear Real Arithmetic (LRA), Real Difference Logic (RDL), their combination (LIRA), Equalities and Uninterpreted Functions (EUF), Bit-Vectors (BV), and Arrays (A). The following solvers are supported through native APIs: MathSAT, Z3, CVC4, Yices, CUDD, PicoSAT, and Boolector. Additionally, you can use any SMT-LIB 2 compliant solver. PySMT assumes that the python bindings for the SMT Solver are installed and accessible from your PYTHONPATH.