If you have postfix configured in your /etc/mail/mailer.conf (answered yes to the previous question) and would like to enable postfix to start at boot time, please set these variables in your /etc/rc.conf file: sendmail_enable="YES" sendmail_flags="-bd" sendmail_outbound_enable="NO" sendmail_submit_enable="NO" sendmail_msp_queue_enable="NO" This will disable Sendmail completely. Also, you may wish to disable some Sendmail-specific daily maintenance routines in your /etc/periodic.conf file: daily_status_mail_rejects_enable="NO" daily_status_include_submit_mailq="NO" daily_submit_queuerun="NO" If you are using SASL, you need to make sure that postfix has access to read the sasldb file. This is accomplished by adding postfix to group cyrus and making the /usr/local/etc/sasldb* file(s) owned by group cyrus.