If you have postfix configured in your /etc/mail/mailer.conf (answered yes to the previous question) and would like to enable postfix to start at boot time, please set these variables in your /etc/rc.conf file: sendmail_enable="YES" sendmail_flags="-bd" sendmail_outbound_enable="NO" sendmail_submit_enable="NO" sendmail_msp_queue_enable="NO" **OR** sendmail_enable="NONE" then type this command as root: ln -s /usr/local/sbin/postfix /usr/local/etc/rc.d/postfix.sh Either of these will disable Sendmail completely. The latter form is useful if you need to wait until other local package initialization (such as ldconfig for Postgres or MySQL) is done. The former method will start postfix very early on in the boot process. Also, you will want to disable some Sendmail-specific daily maintenance routines in your /etc/periodic.conf file: daily_status_mail_rejects_enable="NO" daily_status_include_submit_mailq="NO" daily_submit_queuerun="NO" If you are using SASL, you need to make sure that postfix has access to read the sasldb file. This is accomplished by adding postfix to group mail and making the /usr/local/etc/sasldb* file(s) readable by group mail (this should be the default for new installs).