To finish installation please reconfigure sendmail to use MIMEDefang filter, for example add this lines to your sendmail.mc MAIL_FILTER(`mimedefang', `S=local:/var/spool/MIMEDefang/mimedefang.sock, F=T, T=C:15m;S:4m;R:4m;E:10m')dnl define(`confINPUT_MAIL_FILTERS', `mimedefang')dnl