PyVISA started as wrapper for the NI-VISA library and therefore you need to install National Instruments VISA library in your system. This works most of the time, for most people. But NI-VISA is a proprietary library that only works on certain systems. That is when PyVISA-py jumps in. Starting from version 1.6, PyVISA allows to use different backends. These backends can be dynamically loaded. PyVISA-py is one of such backends. It implements most of the methods for Message Based communication (Serial/USB/GPIB/Ethernet) using Python and some well developed, easy to deploy and cross platform libraries.