********************************************************* Note on environment variables: HMMER reads three environment variables: HMMERDB - directory location of HMM databases (e.g. PFAM) BLASTDB - directory location of FASTA-formatted sequence databases BLASTMAT - directory location of PAM scoring matrices If you have installed BLAST, you probably already have these environment variables set in system-wide or user-specific .cshrc files. They are optional. If they are set up, you can simplify command lines to: > hmmpfam pfam my.query > hmmsearch my.hmm swiss35 instead of > hmmpfam /some/long/path/to/databases/pfam my.query > hmmsearch my.hmm /some/long/path/to/databases/swiss35 Please see the website http://hmmer.wustl.edu/ for more information. *********************************************************