C-Blosc2 is the new major version of C-Blosc, and is backward compatible with both the C-Blosc1 API and its in-memory format. Python-Blosc2 is a Python package that wraps C-Blosc2, the newest version of the Blosc compressor. Currently Python-Blosc2 already reproduces the API of Python-Blosc, so it can be used as a drop-in replacement. However, there are a few exceptions for a full compatibility. In addition, Python-Blosc2 aims to leverage the new C-Blosc2 API so as to support super-chunks, multi-dimensional arrays (NDArray), serialization and other bells and whistles introduced in C-Blosc2. Although this is always and endless process, we have already catch up with most of the C-Blosc2 API capabilities. Note: Python-Blosc2 is meant to be backward compatible with Python-Blosc data. That means that it can read data generated with Python-Blosc, but the opposite is not true (i.e. there is no forward compatibility).