Genetic variant annotation and functional effect prediction toolbox. It
annotates and predicts the effects of genetic variants on genes and proteins
(such as amino acid changes).

Features:

    Supports over 38,000 genomes
    Standard ANN annotation format
    Cancer variants analysis
    GATK compatible (-o gatk)
    HGVS notation
    Sequence Ontology standardized terms

WWW: http://snpeff.sourceforge.net/